Sage X3 has a nice route management inquiry (CONSCSG) that is useful for outbound logistics management. This inquiry/workbench allows the logistics manager to pull up all the deliveries for an assigned truck route for the day and then manually reorder the deliveries so that the driver has clear instructions on how the stops should be performed on the route. A helpful enhancement to this function would be a route optimization button that would automatically order the deliveries in the most optimal/shortest route path manner.
Here is a whitepaper that I found that details this concept, it is based on Dijkstra's shortest path algorithm with considerations for traffic.